Search results for "ENVIRONMENTALLY RELEVANT LEVELS"

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A multi-generational study on low-dose BPA exposure in Wistar rats: Effects on maternal behavior, flavor intake and development

2012

Bisphenol A (BPA) is a common endocrine disruptor found as an environmental and food contaminant. It exerts both developmental and behavioral effects, mainly when exposure occurs in early life. The aim of this study was to determine the multi-generational effects of chronic, human-relevant low-dose exposure to BPA on development, maternal behavior and flavor preference in Wistar rats. BPA was orally administered at a daily dose of 5 mu g/kg body weight to FO pregnant dams from the first day of gestation (GD 1) until the last day of lactation (LD 21), and then to Fl offspring from weaning (PND 21) to adulthood (PND 100). F2 offspring were not exposed. Development and clinical signs of toxici…

Male[ SDV.AEN ] Life Sciences [q-bio]/Food and Nutrition[ SDV.TOX ] Life Sciences [q-bio]/ToxicologyToxicology[ SDV.BA ] Life Sciences [q-bio]/Animal biologyEatingPregnancyLactationBirth RateMaternal BehaviorPerinatal ExposureChemistryTaste preferencesBISPHENOL-A EXPOSURE[SDV.BA]Life Sciences [q-bio]/Animal biologyAnogenital distanceAge FactorsDIETARY EXPOSUREmedicine.anatomical_structureEndocrine disruptorEndocrine disruptorPrenatal Exposure Delayed EffectsENVIRONMENTALLY RELEVANT LEVELS[SDV.TOX]Life Sciences [q-bio]/ToxicologyToxicityMalformationsFemaleCD-1 MICEReproductive toxicityPERINATAL EXPOSUREmedicine.medical_specialtyendocrine systemSEX-DIFFERENCESOffspringGestational AgeAir Pollutants OccupationalREPRODUCTIVE TOXICITYSEXUALLY DIMORPHIC BEHAVIORSFood PreferencesCellular and Molecular NeurosciencePhenolsDevelopmental NeuroscienceInternal medicinemedicineAnimalsWeaningSex RatioBenzhydryl CompoundsRats WistarSPRAGUE-DAWLEY RATSOFFSPRING TOXICITYBody WeightRatsFlavoring AgentsEndocrinologyAnimals NewbornF2 body weight change[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
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